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  Topic: Science Break, Selected Shorts< Next Oldest | Next Newest >  

Posts: 1377
Joined: June 2008

(Permalink) Posted: Nov. 01 2012,15:29

Early evolution of efficient enzymes and genome organization

Abstract (provisional)
Cellular life with complex metabolism probably evolved during the reign of RNA, when it served as both information carrier and enzyme. Jensen proposed that enzymes of primordial cells possessed broad specificities: they were generalist. When and under what conditions could primordial metabolism run by generalist enzymes evolve to contemporary-type metabolism run by specific enzymes?

Here we show by numerical simulation of an enzyme-catalyzed reaction chain that specialist enzymes spread after the invention of the chromosome because protocells harbouring unlinked genes maintain largely non-specific enzymes to reduce their assortment load. When genes are linked on chromosomes, high enzyme specificity evolves because it increases biomass production, also by reducing taxation by side reactions.

The constitution of the genetic system has a profound influence on the limits of metabolic efficiency. The major evolutionary transition to chromosomes is thus proven to be a prerequisite for a complex metabolism. Furthermore, the appearance of specific enzymes opens the door for the evolution of their regulation.


My take: another nail in the "islands of function" meme that Gardon "Golfball Through a Gardenhose" Mullings likes to abuse.

Iím referring to evolution, not changes in allele frequencies. - Cornelius Hunter
Iím not an evolutionist, Iím a change in allele frequentist! - Nakashima

  1753 replies since July 16 2008,08:10 < Next Oldest | Next Newest >  

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