Albatrossity2
Posts: 2780
Joined: Mar. 2007
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I predict the IDiots will completely misrepresent and misunderstand this paper in the Nov. 5 Science (may be behind a firewall for some).
| Quote | Mutational Robustness of Ribosomal Protein Genes
Peter A. Lind, Otto G. Berg, Dan I. Andersson
The distribution of fitness effects (DFE) of mutations is of fundamental importance for understanding evolutionary dynamics and complex diseases and for conserving threatened species. DFEs estimated from DNA sequences have rarely been subject to direct experimental tests. We used a bacterial system in which the fitness effects of a large number of defined single mutations in two ribosomal proteins were measured with high sensitivity. The obtained DFE appears to be unimodal, where most mutations (120 out of 126) are weakly deleterious and the remaining ones are potentially neutral. The DFEs for synonymous and nonsynonymous substitutions are similar, suggesting that in some genes, strong fitness constraints are present at the level of the messenger RNA. |
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Flesh of the sky, child of the sky, the mind
Has been obligated from the beginning
To create an ordered universe
As the only possible proof of its own inheritance.
- Pattiann Rogers
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