Daniel Smith
Posts: 970
Joined: Sep. 2007
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[quote=JAM,Oct. 16 2007,15:07] | Quote (Daniel Smith @ Oct. 16 2007,14:00) | | Quote (David Holland @ Oct. 15 2007,15:51) | | Quote (Daniel Smith @ Oct. 14 2007,10:20) | [EDIT]
Speaking of predictions, I have another one for you:
It's my hypothesis that random mutations are only neutral or deleterious - never advantageous. All advantageous mutations are non-random and are therefore experimentally repeatable and will occurr too rapidly to be random.
Therefore, I predict that anytime Acromobacter guttatus Sp. K172 is subjected to an environment where it must consume nylon to survive, the same frame shift will occur, resulting in Flavobacterium Sp. KI72.
Better? |
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I want to go back to this one for a minute. Suppose I set up a vat with a bazillion Acromobacter guttatus and nylon as the primary source of carbon. If one of the bacteria developes the ability to digest nylon has your hypothesis been supported? Without numbers I can't tell. |
Only if it develops the same exact frame shift and only if it happens consistenty faster than random mutation rates can account for.
BTW, I don't have any idea what those rates are, but I'm sure whoever was doing the test would get that info first. |
What does your hypothesis predict if a different bacterial species is selected on nylon? |
I've already made my prediction, why are asking me to make another one? | Quote |
1) Will multiple selections give the same result, and/or
2) Will the enzymes that evolved be the orthologs of the ones that evolved in Achromobacter?
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My prediction was that exactly the same frame shift will occur - so I'm guessing it will be #1. | Quote |
P.S. Did you check out the mouse vs. rat sequences yet? |
I've been there several times. Let me give you a blow by blow of my most recent visit:
I want to see the mouse and rat genomes side by side so I go to VISTA and select the Mouse Feb. 2006 genome as a base genome, then I figure the best place to start is at the beginning, so I select ch1:1-1000000 and click GO, I get an error saying "No such contig. or chromosome". This is a bit confusing. How can the mouse genome not have a chromosome 1? So then I select ch2:1-1000000 and get the same error. Ch3 and 4 give the same results. So then I decided to try the Rat June 2003 and go with the default chr10:10000001-10100000, which then gives me some results. I click on Browse alignment so I can see the coding (the Cs, As, Ts, and Gs). I zoom in on a spot and when I put my mouse over the Rat code, it gives the number 10034062, when I cursor over the Mouse genome in the same spot, it gives the number 5312532. I'm assuming these are the numbers for the position of that site within the chromosome. So, (if that's the case) it's not showing me the Rat and Mouse genomes, side by side - starting at position 10000001 and ending at position 10100000. If it was, they'd both give the number 10034062 - wouldn't they?
So, like I said, I'm not sure what I'm looking at and I'm not sure the correct way to use the site, but it doesn't appear to be giving me what I was looking for. So, if you have something you want me to see, you'll have to specifically tell me what it is I'm looking at and how it reflects on my hypothesis.
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"If we all worked on the assumption that what is accepted as true is really true, there would be little hope of advance." Orville Wright
"The presence or absence of a creative super-intelligence is unequivocally a scientific question." Richard Dawkins
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