mitschlag
Posts: 236
Joined: Sep. 2006
|
| Quote (Henry J @ Oct. 10 2007,15:00) | | What's makes a site synonymous? |
| Quote | | Nucleotide substitutions in genes coding for proteins can be either synonymous (do not change amino acid), alternatively called silent substitutions, or non-synonymous (changes amino acid). Usually, most non-synonymous changes would be expected to be eliminated by purifying selection, but under certain conditions Darwinian selection may lead to their retention. Investigating the number of synonymous and non-synonymous substitutions may therefore provide information about the degree of selection operating on a system. |
From http://pubmlst.org/software/analysis/start/manual/dsdn.shtml
--------------
"You can establish any “rule” you like if you start with the rule and then interpret the evidence accordingly." - George Gaylord Simpson (1902-1984)
|
