JAM
Posts: 517
Joined: July 2007
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| Quote (Daniel Smith @ Oct. 10 2007,02:30) | | Quote (mitschlag @ Oct. 08 2007,07:02) | | Quote (Daniel Smith @ Oct. 08 2007,04:27) | Take two members of the same species that have been geographically and reproductively isolated for a long period of time (the longer the better), sequence their genomes and compare them.
My prediction is that the coding and non-coding sequences (basically all sequences) will show an equal amount of evolutionary constraint. |
Please define "evolutionary constraint."
Predict the expected results that would falsify your hypothesis. |
I am using the term "evolutionary constraint" to mean a sequence that resists or rejects mutations.
As I understand it, this is the common usage of the term.
The results that would falsify my hypothesis would be if the coding sequences showed evolutionary constraint while the non-coding sequences didn't. |
By "coding," do you mean more than protein-coding sequences, including things like promoters, enhancers, splicing signals, etc.?
Here's an opposing hypothesis:
Known functional sequences will be evolutionarily conserved. Most sequences will not be conserved. We will continue to find functions for some conserved sequences for which no function has been identified.
What do you think? Shall we look at the evidence to see which hypothesis is better supported?
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