ericmurphy
Posts: 2460
Joined: Oct. 2005
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| Quote (afdave @ Dec. 06 2006,12:42) | Eric ... you must have forgotten this quote I posted from the same Kimura article ... | Quote | | Finally, there is one biological problem that we have to consider. Under the present model, effectively neutral, but, in fact, very slightly deleterious mutants accumulate continuously in every species |
So Kimura equates 'effectively neutrals' with VSDMs.
Also remember ...
| Quote | KONDRASHOV'S QUESTION
A.S. Kondrashov. 1995. Contamination of the genome by very slightly deleterious mutations [VSDMs]: Why have we not died 100 times over? J Theor. Biol. 175:583-594.
"accumulation of VSDMs in a lineage ... acts like a timebomb ... the existence of vertebrate lineages ... should be limited to 10^6-10^7 generations." |
How can this be a problem for Dr. Kondrashov, but not for 'Dr.' Murphy?art. |
Dave, you've failed to explain how mutations which, in your own words, have no impact on fitness or reproduction are "very slightly deleterious." Regardless of what you think Kimura is saying, if a mutation has no impact on fitness or reproduction, then it is neutral. There's simply no getting around that.
And where's your explanation for how extinction doesn't get rid of deleterious mutations when they pile up beyond a certain point? It's pointed out to you to the point of exhaustion that 99% of everything that's ever lived is now extinct. So what's your point, Dave?
Also, look at the dates on your sources, Dave. 1979 for Kimura, 1995 for Kondrashov. You might want to look at more recent papers to see if these problems have been resolved. But even if they haven't, that doesn't even BEGIN to mean it's time to toss the ToE in the trash. It merely means more research is required. It most certainly doesn't mean, "Well then God musta did it."
And I'm growing weary of your impuging my education, Dave. My education is what it is, and given your status (undergrad EE with no training whatsoever in any science), you might want to think twice before impugning someone else's education.
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2006 MVD award for most dogged defense of scientific sanity
"Atheism is a religion the same way NOT collecting stamps is a hobby." —Scott Adams
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