deadman_932
Posts: 3094
Joined: May 2006
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| Quote (Daniel Smith @ Feb. 02 2009,18:40) | I read the paper.
It describes another working biosynthetic pathway for lysine within Thermus thermophilus - which is, I'm guessing by the name, a hot water bacteria.
They then do what virtually every (recent) paper I've ever read on the subject of evolution does: they create a phylogenetic tree based on similarities of genome sequence among any number of organisms.
So they've shown varying similarity of sequence.
So how does this support your 3 step pathway? | Quote | (1) an initial ATP-utilizing sequence leads to
(2) the Miyazaki-based alpha aminoadipate Lysine producing sequence in archaeons
(3) and gives rise to to the DAP lysine pathway in E. coli
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Similarity of sequence doesn't translate into workable biosynthetic pathways in totally different organisms. It also doesn't explain how we got here from there. How did we get from (1) to (2)? From (2) to (3)?
If you truly want to meet my challenge, it's not enough to point to working systems and say "connect the dots yourself". You've got to actually show a concrete workable pathway between them. Otherwise all you've done is blow smoke. |
Gee, Daniel, you've conveniently ignored what I said here:
| Quote | | Plug the paper title into Google Scholar, for example, and you get immediate hits describing models of how the DAP and AAA lysine-production routes came about. |
See, 'cause if you'd actually bothered to do that, you'd have gotten the IMMEDIATE hits that you could have followed up on.
I've said I'm unwilling to do your work for you or "teach" you because you've already shown me that you will then just simply move your goalposts to "where did THAT come from?!?!" in search of a place to insert your God of the Gaps (I can suggest ...eh, nevermind) You forget that I've already TRIED that route, Denial, and I didn't like your goalpost-shifting and other games. The VERY FIRST thing you then asked for was a molecule-by-molecule explanation of abiogenesis itself. This meant that not only would i be spoon-feeding you, I'd have to write a whole fuckin' textbook worth of posts just for you to make a face, spit up, and demand that I work backwards until you found your Gap to stick a God in.
ANYWAY...IF you'd bothered to follow up on your own, in your terrible thirst for knowledge (*snort*), what would you have found?
Why, you'd find things like:
Fondi M, Brilli M, Emiliani G, Paffetti D, Fani R. (2007) The primordial metabolism: an ancestral interconnection between leucine, arginine, and lysine biosynthesis.BMC Evol Biol. 2007 Aug 16;7 Suppl 2:S3. http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1963480
Miyazaki J, Kobashi N, et al.(2002) Characterization of a lysK gene as an argE homolog in Thermus thermophilus HB27 FEBS Lett. 2002 Feb 13;512(1-3):269-74
and
Velasco AM, Leguina JI, Lazcano A.(2002) Molecular evolution of the lysine biosynthetic pathways. J Mol Evol. 2002 Oct;55(4):445-59
and hundreds more.
So...Denial...now we come to the real questions. WHY didn't YOU do that?
(1) Are you so intellectually lazy that you needed ME to plug the Nishida article into Google scholar and follow the citations? Or
(2) Are you so intellectually dishonest that you won't actually read material bearing on the problems you claim to be interested in? Or
(3) Is it both?
Hell, Denial, let's be honest here...you're NOT INTERESTED in anything but "witnessing" and you're not interested in even straining your dainty intellect even to plug a cite into Google Scholar as I suggested...because the results might not be pleasing to you and you'd get the vapors. Piss off.
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AtBC Award for Thoroughness in the Face of Creationism
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