Texas Teach
Posts: 2084
Joined: April 2007
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| Quote (stevestory @ Oct. 13 2020,18:06) | | Quote (Texas Teach @ Oct. 13 2020,17:21) | | Quote (stevestory @ Oct. 13 2020,13:40) | Regarding those Trumper numb nuts who think that they’re just going to get hurt immunity through massive infection rates | Quote |
Summary
Background
The degree of protective immunity conferred by infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is currently unknown. As such, the possibility of reinfection with SARS-CoV-2 is not well understood. We describe an investigation of two instances of SARS-CoV-2 infection in the same individual.
Methods
A 25-year-old man who was a resident of Washoe County in the US state of Nevada presented to health authorities on two occasions with symptoms of viral infection, once at a community testing event in April, 2020, and a second time to primary care then hospital at the end of May and beginning of June, 2020. Nasopharyngeal swabs were obtained from the patient at each presentation and twice during follow-up. Nucleic acid amplification testing was done to confirm SARS-CoV-2 infection. We did next-generation sequencing of SARS-CoV-2 extracted from nasopharyngeal swabs. Sequence data were assessed by two different bioinformatic methodologies. A short tandem repeat marker was used for fragment analysis to confirm that samples from both infections came from the same individual.
Findings
The patient had two positive tests for SARS-CoV-2, the first on April 18, 2020, and the second on June 5, 2020, separated by two negative tests done during follow-up in May, 2020. Genomic analysis of SARS-CoV-2 showed genetically significant differences between each variant associated with each instance of infection. The second infection was symptomatically more severe than the first.
Interpretation
Genetic discordance of the two SARS-CoV-2 specimens was greater than could be accounted for by short-term in vivo evolution. These findings suggest that the patient was infected by SARS-CoV-2 on two separate occasions by a genetically distinct virus. Thus, previous exposure to SARS-CoV-2 might not guarantee total immunity in all cases. All individuals, whether previously diagnosed with COVID-19 or not, should take identical precautions to avoid infection with SARS-CoV-2. The implications of reinfections could be relevant for vaccine development and application
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The Lancet |
I wonder if he’s really unlucky, or if he was counting on immunity and was foolhardy before the second one. |
He could’ve been an isolated case. But in general, it’s not possible to have herd immunity from a disease without a vaccine for the disease. And nobody knows if we’ll be able to make a vaccine for this thing. Sars cov 2 could wind up being an endemic disease that we have for the forseeable future. |
I’m thinking the best we can hope for is getting something akin to the flu shots of years ago that give some immunity but mostly tamp down the severity.
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"Creationists think everything Genesis says is true. I don't even think Phil Collins is a good drummer." --J. Carr
"I suspect that the English grammar books where you live are outdated" --G. Gaulin
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