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Daniel Smith



Posts: 970
Joined: Sep. 2007

(Permalink) Posted: Mar. 06 2008,19:03   

Quote (swbarnes2 @ Mar. 05 2008,12:12)
I think that a fair bit of what any of us would have to say has already been covered in the panda's thumb review of this paper.

Another example of “scholarship”

I also add the contents of "the onion test"

Junk DNA, Junk Science, and The Onion Test

And Daniel, if you fail to say anything intelligent or fact-based in response...well, we'll know that you have neither anything intelligent nor factual to say.

No one will be surprised.

I read the panda's thumb review.  One thing I noticed is that Ian Musgrave, the panda's thumb author, focused in on one fairly insignificant element in the paper - reproductive rates - and used perceived mistakes relating to said rates as an excuse to ignore the rest of the paper.  Hardly fair I'd say, since Shapiro and Sternberg don't make much of an issue about reproduction rates. Here's a portion of the review:        
Quote
One of the challenges to the idea that the majority of non-coding DNA is doing something useful is the existence of organisms like the puffer fish Fugu. Despite being a fairly complex vertebrate, with roughly similar number of genes to humans, it has between half to one-third the non-coding DNA that other vertebrates (and non-vertebrates) have. So what do Shapiro and von Sternberg say about Fugu? Their only mention is this:

   “Rapidly reproducing organisms, like Caenorhabditis, Drosophila, Fugu and Arabidopsis, tend to have stripped-down genomes with relatively less abundant repetitive DNA, while organisms with longer life cycles, such as humans and maize, have larger genomes with correspondingly more repetitive elements (Table 1).”

However, their own table shows that this is nonsense.

In order of reproductive rate
Organism,  % Genome repetitive DNA,  Reproduction rate
Caenorhabditis briggsae, 22%,  approx 25-50 times per year
Drosophila (fuit fly),  34-57%*,  6-12 times per year
Clionia(tunicate),  35%,  several times to once per year
Mouse,  40%,  3-4 times a year
Fugu,  15%,  Once per year
Dog,  31%,  Once per year+


First off, the quote leaves out an important part of the context.  Here's the whole thing:        
Quote
The second overlooked aspect is the significance of
genome size and of distance between distinct regions of the
genome
. Rapidly reproducing organisms, like Caenorhabditis,
Drosophila, Fugu and Arabidopsis tend to have stripped-down
genomes with relatively less abundant repetitive DNA, while
organisms with longer life cycles, such as humans and
maize, have larger genomes with correspondingly more
repetitive elements (Table 1; Cavalier-Smith, 1985).
They are talking about trends here - not hard fast rules.  Their main focus being not reproduction rates, but the "genome size and of distance between distinct regions of the genome".
If you look at the table as it appears in the paper, you'll see that it is just a listing showing significant statistics related to 1) Genome size, 2) % repetitive DNA, and 3) % coding sequences.  Musgrave's table adds reproduction rates and leaves out 'genome size' and '% coding sequences'.  These elements add an important ratio to the equation.  When left out, it gives the false impression that the authors are falsifying data.

So Musgrave finds an insignificant perceived flaw and magnifies it to such a level as to give the impression that none of Shapiro and Sternberg's work can be trusted.

Of course no one here will let that influence them.  I'm sure you would all rather make up your own minds about this.   So you'll go and read the paper yourselves, with an open mind, to see if Shapiro and Sternberg actually make a good case.

Right?

--------------
"If we all worked on the assumption that what is accepted as true is really true, there would be little hope of advance."  Orville Wright

"The presence or absence of a creative super-intelligence is unequivocally a scientific question."  Richard Dawkins

  
Daniel Smith



Posts: 970
Joined: Sep. 2007

(Permalink) Posted: Mar. 06 2008,19:11   

Quote (blipey @ Mar. 05 2008,17:18)
 
Quote (Daniel Smith @ Mar. 05 2008,18:41)
   
Quote (blipey @ Mar. 05 2008,10:13)
Wow.  Your response is "There are two authors"?

Really.  No address of the issue of evidence and testing of hypothesis?  Just noting the fact that there are two authors?

Did the second author bother to test anything?  Does there being a second author somehow advance your case? Or answer the question?

I was at work.  I didn't have time for a thorough response.  

As for evidence, there's a table that spans six pages listing the evidence for functional repetitive DNA.

Did you look at it?

Yes. The table you speak of is found in a section titled "DOCUMENTATION OF DIVERSE GENOMIC
FUNCTIONS ASSOCIATED WITH DIFFERENT
CLASSES OF REPETITIVE DNA ELEMENTS".

It is a list of repetitive DNA elements just as it says.  It is not really (I may be wrong--not reading biology papers for a living) evidence of their conclusion.

It seems to be a list of things that exist.  To cite that as evidence of their conclusion seems incorrect.  It would rather be like me concluding "Baseball is the Best Sport" and claiming as evidence the following table:

1.  There are 4 bases
2.  3 strikes and you're out
3.  There are 90 feet between bases

I may be wrong, of course.  I'll leave it to professionals to correct me (as I often need correcting).

The first column in the table is labeled "Function", the last is labeled "Reference".  The rows of the table are sorted for... "Function".  There are columns labeled "Structural Class" and "Example" which would qualify as "things that exist".  But, as a whole, the table is designed so you can look at the claimed functions for these "things that exist" and check the cited references to see if the claims are valid.

Apparently you skimmed through it so fast, you missed those key elements.

--------------
"If we all worked on the assumption that what is accepted as true is really true, there would be little hope of advance."  Orville Wright

"The presence or absence of a creative super-intelligence is unequivocally a scientific question."  Richard Dawkins

  
Daniel Smith



Posts: 970
Joined: Sep. 2007

(Permalink) Posted: Mar. 06 2008,19:13   

Quote (swbarnes2 @ Mar. 05 2008,17:37)
 
Quote (Daniel Smith @ Mar. 05 2008,18:41)

As for evidence, there's a table that spans six pages listing the evidence for functional repetitive DNA.


And how many of those functions for repetative DNA were found by Creationists?

So you're hip to them being "functions" now?

--------------
"If we all worked on the assumption that what is accepted as true is really true, there would be little hope of advance."  Orville Wright

"The presence or absence of a creative super-intelligence is unequivocally a scientific question."  Richard Dawkins

  
Daniel Smith



Posts: 970
Joined: Sep. 2007

(Permalink) Posted: Mar. 06 2008,19:21   

Quote (mitschlag @ Mar. 05 2008,04:38)
 
Quote (Daniel Smith @ Mar. 04 2008,18:33)
Schindewolf speaks at length about Orthogenesis.  If I understand it correctly, his views were that evolution followed repeatable patterns, was irreversible, eventually led to overspecialization and ultimately ended in extinction.

Of the description you quote I'd say this much applies to Schindewolf's view:          
Quote
Orthogenesis ... refers to the idea that an evolutionary lineage changes [in a] steady, uniform way with no reversals. Species [are not] evolving steadily towards a goal, [rather the path they were set on was "decided" by the saltational event that first formed that type].  [T]his trend was [not] caused by some “mysterious inner force” (to use Simpson’s words) of the species that compelled it to evolve. [Rather, Schindewolf] would say that once a trend got started in a lineage, it would unchangingly continue until extinction occurred.

Thanks for the clarification.

GG Simpson and others who worked in the field found that Schindewolf's orthogenesis theory did not fit the evidence of horse evolution:


Schindewolf used the example of horse evolution as evidence for an orthogenetic trend towards phyletic size increase. (See figures 3.130-35 on page 292)

I think your chart fairly supports that conclusion as well.

The thing I'm finding most often is that those who criticized Schindewolf often don't seem to have taken the time to try to fully understand his positions and the reasoning behind them.

--------------
"If we all worked on the assumption that what is accepted as true is really true, there would be little hope of advance."  Orville Wright

"The presence or absence of a creative super-intelligence is unequivocally a scientific question."  Richard Dawkins

  
swbarnes2



Posts: 78
Joined: Mar. 2006

(Permalink) Posted: Mar. 06 2008,20:14   

[quote=Daniel Smith,Mar. 06 2008,19:03]
Quote
They are talking about trends here - not hard fast rules.”


Sigh.

Do the data they present support the claim to see?  Yes, or no?

Quote
If you look at the table as it appears in the paper, you'll see that it is just a listing showing significant statistics related to 1) Genome size, 2) % repetitive DNA, and 3) % coding sequences.”


Okay, so when you graph the data they present, does the graph support the “trend” they claim?  Or is their trend nonsense, and they threw data in the paper to make it look factual, when it’s not?  Does it support a “trend” between less repetitive DNA and reproductive cycle times?  

Quote
Musgrave's table adds reproduction rates and leaves out 'genome size' and '% coding sequences'.  These elements add an important ratio to the equation.”


He leaves out the coding percentage but since the claim isn’t about coding percentages, but repetitive percentages, leaving that out doesn’t alter a thing.

Musgrave’s table has the percentage of repetitive sequences.  For goodness sakes, we can all go to the link and see that ourselves.  

Oh wow…you honestly don’t think that a percentage is a ratio, do you?

This is priceless, and very Creationist of you to not understand middle school math. Okay, I won’t accuse you of dishonesty on this one.  I’ll do you the charity of assuming that you are too stupid to realize that what you said is nonsense.

Well, I think we can scratch "intelligent" off the list of adjectives describgin this post.

Quote
When left out, it gives the false impression that the authors are falsifying data.”


No, it doesn’t.  It gives the correct impression that the authors’ conclusion can’t be drawn from their data.

But one doesn’t expect a person who thinks that percentages aren’t ratios to understand that.

Quote
So you'll go and read the paper yourselves, with an open mind, to see if Shapiro and Sternberg actually make a good case.”


Sure, some repetitive DNA has function.  But that case was made years ago, by all the real scientists who did the research and wrote the papers that those two guys cited.

But that doesn’t prove that all, or even most of non-coding DNA does anything.

You want to impress us with your scientific integrity, it’s very simple.

What do you predict would happen if say, a chunk of DNA a million bases long which was known to have no coding DNA were totally deleted from, say, the mouse genome?

What do you predict the mouse would be like?

Put your money where your mouth is, or continue to prove that you have thrown your integrity in the toilet for Creationism.

  
Tracy P. Hamilton



Posts: 1239
Joined: May 2006

(Permalink) Posted: Mar. 06 2008,21:20   

Quote (Daniel Smith @ Mar. 06 2008,19:21)
Quote (mitschlag @ Mar. 05 2008,04:38)
 
Quote (Daniel Smith @ Mar. 04 2008,18:33)
Schindewolf speaks at length about Orthogenesis.  If I understand it correctly, his views were that evolution followed repeatable patterns, was irreversible, eventually led to overspecialization and ultimately ended in extinction.

Of the description you quote I'd say this much applies to Schindewolf's view:            
Quote
Orthogenesis ... refers to the idea that an evolutionary lineage changes [in a] steady, uniform way with no reversals. Species [are not] evolving steadily towards a goal, [rather the path they were set on was "decided" by the saltational event that first formed that type].  [T]his trend was [not] caused by some “mysterious inner force” (to use Simpson’s words) of the species that compelled it to evolve. [Rather, Schindewolf] would say that once a trend got started in a lineage, it would unchangingly continue until extinction occurred.

Thanks for the clarification.

GG Simpson and others who worked in the field found that Schindewolf's orthogenesis theory did not fit the evidence of horse evolution:


Schindewolf used the example of horse evolution as evidence for an orthogenetic trend towards phyletic size increase. (See figures 3.130-35 on page 292)

I think your chart fairly supports that conclusion as well.

The thing I'm finding most often is that those who criticized Schindewolf often don't seem to have taken the time to try to fully understand his positions and the reasoning behind them.

florida natural history museum says

"Were all fossil horses larger than their ancestors?
Archaeohippus means ancient horse
Though many horses became larger than their ancestors, Archaeohippus actually became quite a bit smaller! Archaeohippus descended from the larger Miohippus. Nannippus is another example of a horse that was smaller than its ancestors."

Another theory slain by TWO ugly facts.

--------------
"Following what I just wrote about fitness, you’re taking refuge in what we see in the world."  PaV

"The simple equation F = MA leads to the concept of four-dimensional space." GilDodgen

"We have no brain, I don't, for thinking." Robert Byers

  
JAM



Posts: 517
Joined: July 2007

(Permalink) Posted: Mar. 06 2008,21:27   

Quote (Daniel Smith @ Mar. 06 2008,19:03)
So you'll go and read the paper yourselves, with an open mind, to see if Shapiro and Sternberg actually make a good case.

Right?

Dude, wouldn't we look at the EVIDENCE before deciding whether they make a good case?

You're all about evidence, right?
Quote (Daniel Smith @ Sep. 22 2007,04:48)

My main problem is that I want to see unbiased and unadulterated evidence; not evidence that is made-to-fit the observers viewpoint...I decided what I needed was just to see the evidence for myself.

Daniel, you're citing a review in a low-tier journal. It's clear that you're afraid of unbiased and unadulterated evidence, and that you are afraid to examine the evidence for yourself. You desperately need someone to tell you what to think.

Why did you tell such blatant lies when you arrived here?

  
Tracy P. Hamilton



Posts: 1239
Joined: May 2006

(Permalink) Posted: Mar. 06 2008,21:40   

Quote (Daniel Smith @ Mar. 06 2008,19:03)
 
Quote (swbarnes2 @ Mar. 05 2008,12:12)
I think that a fair bit of what any of us would have to say has already been covered in the panda's thumb review of this paper.

Another example of “scholarship”

I also add the contents of "the onion test"

Junk DNA, Junk Science, and The Onion Test

And Daniel, if you fail to say anything intelligent or fact-based in response...well, we'll know that you have neither anything intelligent nor factual to say.

No one will be surprised.

I read the panda's thumb review.  One thing I noticed is that Ian Musgrave, the panda's thumb author, focused in on one fairly insignificant element in the paper - reproductive rates - and used perceived mistakes relating to said rates as an excuse to ignore the rest of the paper.


In other words, Ian Musgrave points out that their explanation for Fugu's lack of junk doesn't hold water, and you call it a fairly insignificant point about a paper that claims junk is essential????

Quote
Ian:"The Fugu data is not the only evidence that most non-coding DNA is functionless. To start with the single celled amoeba has a genome 200 times larger than the human genome, most of it repetitive DNA. It would be hard to argue that the amoeba needs far more repetitive DNA than humans to organise its genome."


Doesn't sound like ignoring the evidence for junk being junk, and just nitpicking about reproductive rates.

Quote
Ian:
"Furthermore, we have evidence from sequence conservation. If the repetitive DNA has a function, then its sequence should be conserved (for example if it serves as binding sites for regulatory proteins). However, the majority of the repetitive DNA is not conserved. Indeed, Kimura famously predicted that humans should have around about 1% protein coding genes based on mutation patterns (Kimura and Ohta, 1971). We actually have roughly 1-2% of our genome coding for protein (Nusbaum et al 2005). The sequence conservation data is compatible with over 90% of our genome doing not very much at all (either as regulatory sequences or protein coding sequences). Now, about 3-5% of repetitive DNA is conserved, which suggests that it might do something (Nobrega et al, 2004; Nusbaum et al 2005). So, what happens when this conserved repetitive DNA is removed?

The answer is “beggar all”."


What's that?  Somebody actually deleted this DNA that is claimed to have a function, and it makes no difference to the organism?  Another idea that doesn't survive scrutiny.

How do you choose which papers you accept at face value, and which you do not?  Is it based on the fact that you like the conclusions, or on the reasoning used to arrive at them?

--------------
"Following what I just wrote about fitness, you’re taking refuge in what we see in the world."  PaV

"The simple equation F = MA leads to the concept of four-dimensional space." GilDodgen

"We have no brain, I don't, for thinking." Robert Byers

  
Daniel Smith



Posts: 970
Joined: Sep. 2007

(Permalink) Posted: Mar. 07 2008,00:10   

Quote (Daniel Smith @ Mar. 06 2008,17:03)
They are talking about trends here - not hard fast rules.

That sentence should read: "They are talking about tendencies here - not hard fast rules."

--------------
"If we all worked on the assumption that what is accepted as true is really true, there would be little hope of advance."  Orville Wright

"The presence or absence of a creative super-intelligence is unequivocally a scientific question."  Richard Dawkins

  
oldmanintheskydidntdoit



Posts: 4999
Joined: July 2006

(Permalink) Posted: Mar. 07 2008,03:10   

Quote (Daniel Smith @ Mar. 07 2008,00:10)
 
Quote (Daniel Smith @ Mar. 06 2008,17:03)
They are talking about trends here - not hard fast rules.

That sentence should read: "They are talking about tendencies here - not hard fast rules."

What no edit button?  :D

Daniel, ever heard of phlostigon?

Have a read, then let us know if you think current thinking is in error.
 
Quote
"Phlogisticated" substances are those that contain phlogiston and are "dephlogisticated" when burned; "in general, substances that burned in air were said to be rich in phlogiston; the fact that combustion soon ceased in an enclosed space was taken as clear-cut evidence that air had the capacity to absorb only a definite amount of phlogiston. When air had become completely phlogisticated it would no longer serve to support combustion of any material, nor would a metal heated in it yield a calx; nor could phlogisticated air support life, for the role of air in respiration was to remove the phlogiston from the body."[4] Thus, phlogiston as first conceived was a sort of anti-oxygen.


--------------
I also mentioned that He'd have to give me a thorough explanation as to *why* I must "eat human babies".
FTK

if there are even critical flaws in Gauger’s work, the evo mat narrative cannot stand
Gordon Mullings

  
Daniel Smith



Posts: 970
Joined: Sep. 2007

(Permalink) Posted: Mar. 07 2008,19:25   

[quote=swbarnes2,Mar. 06 2008,18:14]        
Quote (Daniel Smith @ Mar. 06 2008,19:03)

         
Quote
They are talking about trends here - not hard fast rules.”


Sigh.

Do the data they present support the claim to see?  Yes, or no?

Sigh.

Yes it does.  (Hint: reproductive rates are not the focus of their claim and are not part of their data.)  If you search their paper for the partial term "reproduc" (which should catch all references to reproduction) there are only three matches (and the other two are about reproductive isolation).  So making a big deal about reproductive rates is a classic strawman argument.
         
Quote
       
Quote
If you look at the table as it appears in the paper, you'll see that it is just a listing showing significant statistics related to 1) Genome size, 2) % repetitive DNA, and 3) % coding sequences.”


Okay, so when you graph the data they present, does the graph support the “trend” they claim?  Or is their trend nonsense, and they threw data in the paper to make it look factual, when it’s not?  Does it support a “trend” between less repetitive DNA and reproductive cycle times?
 
First off, I should have said "tendency" not "trend" - since "tend to" was the phrase they used.  (I have not been given the privilege of editing my own posts, so I was unable to go back and change that.)
Secondly, is that their claim?  If so, why do they not expound upon it?  Like I said before, it's not presented as if it's a rule - it's a tendency.  There are exceptions to tendencies.  Here are the other places where they reference that table (Table 1) in the paper.  You tell me if reproductive rates are the focus:        
Quote
Fifty years of DNA-based molecular genetics and genome sequencing have revolutionised our ideas about the physical basis of cell and organismal heredity. We now understand many processes of genome expression and transmission in considerable molecular detail, and whole genome sequences allow us to think about the principles that underlie the organisation of cellular DNA molecules. There have been many surprises and new insights. In the human genome, for example, the protein-coding component represents about 1.2% of the total DNA, while 43% of the sequenced euchromatic portion of the genome consists of repeated and mobile DNA elements (International Human Genome Consortium, 2001; Table 1). In addition to dispersed elements, most of the unsequenced heterochromatic portion of the human genome (about 18% of the total) consists of repetitive DNA, both mobile elements and tandemly repeated ‘ satellite ’ DNA. Thus, over half the human genome is repetitive DNA. Table 1 shows that the human genome is far from exceptional in containing a major fraction of repeats. Even in bacteria, repetitive sequences may account for upwards of 5–10% of the total genome (Hofnung & Shapiro, 1999; Parkhill et al., 2000)....

...It is important to note here the little known fact that phenotypic effects of heterochromatin are not necessarily limited to adjacent genetic loci. The strength of heterochromatic silencing on the three large D. melanogaster chromosomes is sensitive to the total nuclear content of heterochromatin carried on the Y chromosome (see Table 1). ...

...Another frequently ignored feature of genome system architecture associated with repeat elements is overall genome size (Cavalier-Smith, 1985). In plants, genome size correlates with an increase in repetitive DNA abundance (Table 1). Plant molecular geneticists have suggested that the total length of each genome is an important functional characteristic, which influences replication time, a characteristic that correlates with the length of the life cycle (Bennett, 1998; Bennetzen, 2000; Petrov, 2001; Vinogradov, 2003). It makes sense that amplification of mobile genetic elements is an efficient method of altering total DNA content in the genome. Similarly, distance between regulatory and coding sequences may be an important control parameter (Zuckerandl, 2002).

Well?    
Quote
       
Quote
Musgrave's table adds reproduction rates and leaves out 'genome size' and '% coding sequences'.  These elements add an important ratio to the equation.”


He leaves out the coding percentage but since the claim isn’t about coding percentages, but repetitive percentages, leaving that out doesn’t alter a thing.

Musgrave’s table has the percentage of repetitive sequences.  For goodness sakes, we can all go to the link and see that ourselves.
 
There are two percentages listed in the table.  Those two percentages, (along with the genome size), paint a picture of "the significance of genome size and of distance between distinct regions of the genome" - which was the part of their claim Musgrave left out.
     
Quote
Oh wow…you honestly don’t think that a percentage is a ratio, do you?

This is priceless, and very Creationist of you to not understand middle school math. Okay, I won’t accuse you of dishonesty on this one.  I’ll do you the charity of assuming that you are too stupid to realize that what you said is nonsense.

Well, I think we can scratch "intelligent" off the list of adjectives describgin this post.

Sigh...
         
Quote
     
Quote
When left out, it gives the false impression that the authors are falsifying data.”


No, it doesn’t.  It gives the correct impression that the authors’ conclusion can’t be drawn from their data.

Which data is that?  Reproduction rates?  That's not their data!
     
Quote
But one doesn’t expect a person who thinks that percentages aren’t ratios to understand that.

Sigh...
         
Quote
     
Quote
So you'll go and read the paper yourselves, with an open mind, to see if Shapiro and Sternberg actually make a good case.”


Sure, some repetitive DNA has function.  But that case was made years ago, by all the real scientists who did the research and wrote the papers that those two guys cited.

But that doesn’t prove that all, or even most of non-coding DNA does anything.

So is that a "Yes" or a "No" about whether or not you'll actually read the paper?  
Quote
You want to impress us with your scientific integrity, it’s very simple.

What do you predict would happen if say, a chunk of DNA a million bases long which was known to have no coding DNA were totally deleted from, say, the mouse genome?

What do you predict the mouse would be like?

Put your money where your mouth is, or continue to prove that you have thrown your integrity in the toilet for Creationism.
 
I already know the answer to that (You see, I actually read the panda's thumb review).  But just because the deletion produced no observable effects doesn't mean the DNA was not functional.
I could probably delete a big chunk of the files on my hard drive with no ill effects.  I would not even notice they were gone until I needed them - which could be months or years later.  The again, I might never notice if they were files used for the one-time setup of my computer.  Yet they are all functional files.

Maybe the chunk deleted from the mouse genome was used during ontogeny and then not used again.  Deleting it would produce no ill effects then.

--------------
"If we all worked on the assumption that what is accepted as true is really true, there would be little hope of advance."  Orville Wright

"The presence or absence of a creative super-intelligence is unequivocally a scientific question."  Richard Dawkins

  
JAM



Posts: 517
Joined: July 2007

(Permalink) Posted: Mar. 08 2008,02:22   

Quote (Daniel Smith @ Mar. 07 2008,19:25)
I could probably delete a big chunk of the files on my hard drive with no ill effects.  I would not even notice they were gone until I needed them - which could be months or years later.

If you never needed them or used them for anything, they are not functional.
Quote
The again, I might never notice if they were files used for the one-time setup of my computer.  Yet they are all functional files.

Are you claiming that these repetitive sequences were deleted after the setup (development) of the mouse?

Do you realize how brain-dead these ID arguments from analogies are, particularly since you aren't even constructing a true analogy?
Quote
Maybe the chunk deleted from the mouse genome was used during ontogeny and then not used again.  Deleting it would produce no ill effects then.

Dan, that has to be one of the most ignorant things you have ever written here, which is saying a lot.

What do we real scientists do when we delete a chunk of the mouse genome?

Are you so dense that you think that a chunk of the genome could be deleted from an adult mouse? How would we get into every cell to do it?

Oh, and when you see that your entire premise was false, will that affect your claimed confidence in your conclusion?

  
JAM



Posts: 517
Joined: July 2007

(Permalink) Posted: Mar. 08 2008,02:26   

Quote (Daniel Smith @ Mar. 07 2008,19:25)
Quote (swbarnes2 @ Mar. 06 2008,18:14)
         
Quote (Daniel Smith @ Mar. 06 2008,19:03)

           
Quote
They are talking about trends here - not hard fast rules.”


Sigh.

Do the data they present support the claim to see?  Yes, or no?

Sigh.

Yes it does.  (Hint: reproductive rates are not the focus of their claim and are not part of their data.)


None of the data are theirs. They don't have sufficient faith in their position to produce any new data. Actions speak louder than words.

"If you search their paper for the partial term "reproduc" (which should catch all references to reproduction) there are only three matches (and the other two are about reproductive isolation)."

The question was about the data, not about the text.

Can't you distinguish the difference?

  
Daniel Smith



Posts: 970
Joined: Sep. 2007

(Permalink) Posted: Mar. 08 2008,11:11   

Quote (JAM @ Mar. 08 2008,00:22)
 
Quote (Daniel Smith @ Mar. 07 2008,19:25)
I could probably delete a big chunk of the files on my hard drive with no ill effects.  I would not even notice they were gone until I needed them - which could be months or years later.

If you never needed them or used them for anything, they are not functional.
 
Quote
The again, I might never notice if they were files used for the one-time setup of my computer.  Yet they are all functional files.

Are you claiming that these repetitive sequences were deleted after the setup (development) of the mouse?

Do you realize how brain-dead these ID arguments from analogies are, particularly since you aren't even constructing a true analogy?
 
Quote
Maybe the chunk deleted from the mouse genome was used during ontogeny and then not used again.  Deleting it would produce no ill effects then.

Dan, that has to be one of the most ignorant things you have ever written here, which is saying a lot.

What do we real scientists do when we delete a chunk of the mouse genome?

Are you so dense that you think that a chunk of the genome could be deleted from an adult mouse? How would we get into every cell to do it?

Oh, and when you see that your entire premise was false, will that affect your claimed confidence in your conclusion?

I realized that after my post.  I was thinking "Oh no, JAMs going to have a field day with that one!"  Oh well.  That's how science works - right?

Oh, and the files on my hard drive are still functional whether I use them or not.  They may not be "functioning" at the moment, but they are still "functional".

Whether or not they are analogous in any way to functioning and functional parts of genomes, I don't know, but I'd suspect they are.

--------------
"If we all worked on the assumption that what is accepted as true is really true, there would be little hope of advance."  Orville Wright

"The presence or absence of a creative super-intelligence is unequivocally a scientific question."  Richard Dawkins

  
Daniel Smith



Posts: 970
Joined: Sep. 2007

(Permalink) Posted: Mar. 08 2008,11:14   

Quote (JAM @ Mar. 08 2008,00:26)
 
Quote (Daniel Smith @ Mar. 07 2008,19:25)

"If you search their paper for the partial term "reproduc" (which should catch all references to reproduction) there are only three matches (and the other two are about reproductive isolation)."

The question was about the data, not about the text.

Can't you distinguish the difference?

Yes.  They present no data on reproduction rates for the organisms discussed.

--------------
"If we all worked on the assumption that what is accepted as true is really true, there would be little hope of advance."  Orville Wright

"The presence or absence of a creative super-intelligence is unequivocally a scientific question."  Richard Dawkins

  
Daniel Smith



Posts: 970
Joined: Sep. 2007

(Permalink) Posted: Mar. 08 2008,15:26   

Quote (JAM @ Mar. 02 2008,16:47)
 
Quote (Daniel Smith @ Mar. 02 2008,12:40)
     
Quote (JAM @ Mar. 01 2008,22:10)
       
Quote (Daniel Smith @ Mar. 01 2008,21:46)
         
Quote (JAM @ Mar. 01 2008,11:18)
Schindewolf's hypothesis was about MORPHOLOGICAL saltation. Can't you read and comprehend the adjective CHROMOSOMAL?

Did Schindewolf even mention chromosomes in his Bib--er, book?

Yes, in notes 21 and 22 on pages 349 and 352 where he speaks of Goldschmidt's Systemmutationen.  
On page 352 he says:                    
Quote
This repatterning, or Systemmutation, is attributed to cytologically provable breaks in the chromosomes, which evoke inversions, duplications, and translocations.  A single modification of an embryonic character produced in this way would then regulate a whole series of related ontogenetic processes, leading to a completely new developmental type.
(his emphasis)

Schindewolf was wrong.

The point you keep missing is that these karyotypically visible events (fission, fusion, inversion, translocation, etc.) can produce speciation with absolutely zero change in phenotype.

On the other hand, a single nucleotide substitution can cause massive phenotypic changes.

Can you manage to wrap your brain around that fundamental point?

I'm aware of the former,...

Since you know he was wrong about that, why would you claim that he was vindicated?
   
Quote
...but can you give me examples of the latter?

Yes; oligodontia, orofacial cleft, optic atrophy, absence of radius, radioulnar synostosis, absence of thumbs, chondrodysplasia, GH insensitivity, split-hand/foot malformation with long bone deficiency, etc.

Let me just clarify something here.  Schindewolf did not spend a lot of time talking about genetic mechanisms because he was not a genetecist.  He knew however, that there had to be some form of mechanism because he saw evidence for it in the fossil record.  He produced extensive data (JAM) documenting the reality of an ontogenetic switch from an established developmental path to a new and different developmental pathway during the early ontogenetic stages of fossilized ammonites and corals.

So he knew evolution happened that way - he had observed it as directly as a paleontologist could - he just didn't know what exact mechanism was behind the observed switch.

He embraced Goldschmidt's systemmutationen because it closely resembled his own observations, but the switch does not have to be chromosomal rearrangements, it could be single nucleotide substitutions (I suppose) provided they affected an early enough stage in ontogeny.

The point being, Schindewolf's theory was based on his direct observations of 'ontogenetical evolution' in the fossil record (as "direct" as can be deduced from the fossil record that is).

--------------
"If we all worked on the assumption that what is accepted as true is really true, there would be little hope of advance."  Orville Wright

"The presence or absence of a creative super-intelligence is unequivocally a scientific question."  Richard Dawkins

  
JAM



Posts: 517
Joined: July 2007

(Permalink) Posted: Mar. 08 2008,19:10   

Quote (Daniel Smith @ Mar. 08 2008,11:14)
Quote (JAM @ Mar. 08 2008,00:26)
   
Quote (Daniel Smith @ Mar. 07 2008,19:25)

"If you search their paper for the partial term "reproduc" (which should catch all references to reproduction) there are only three matches (and the other two are about reproductive isolation)."

The question was about the data, not about the text.

Can't you distinguish the difference?

Yes.  They present no data on reproduction rates for the organisms discussed.

So why your brain-dead text search as a response?

Isn't the point that their claim:
Quote
Rapidly reproducing organisms, like Caenorhabditis,
Drosophila, Fugu and Arabidopsis tend to have stripped-down
genomes with relatively less abundant repetitive DNA, while
organisms with longer life cycles, such as humans and
maize, have larger genomes with correspondingly more
repetitive elements (Table 1 ; Cavalier-Smith, 1985).


Is not only false, but utterly unsupported by the data in Table 1?

  
Wesley R. Elsberry



Posts: 4991
Joined: May 2002

(Permalink) Posted: Mar. 08 2008,19:27   

I think Daniel thinks it is a win if whoever he's backing at the moment can't be accused of obvious self-contradiction. Right or wrong seem to be merely arguable. If someone doesn't support a liked argument with data, that is not only not a fault, but prevents anyone from being able to say that they shot themselves in the foot.

--------------
"You can't teach an old dogma new tricks." - Dorothy Parker

    
blipey



Posts: 2061
Joined: June 2006

(Permalink) Posted: Mar. 08 2008,19:57   

Quote
I realized that after my post.  I was thinking "Oh no, JAMs going to have a field day with that one!"  Oh well.  That's how science works - right?

Oh, and the files on my hard drive are still functional whether I use them or not.  They may not be "functioning" at the moment, but they are still "functional".

Whether or not they are analogous in any way to functioning and functional parts of genomes, I don't know, but I'd suspect they are.


So your response, though self-admittedly wrong, should have no bearing on whether or not the rest of your conclusions can be trusted?  Even when you are so cavalier about being wrong and don't seem to care to alter your argument, explain why you used such a bogus argument, or anything?

As to the functionality argument vis computer files:

Isn't the conclusion that the paper draws: the repeated sequences are necessary FOR the function OF the genome?  This is not the same thing as merely having a function.

Your analogy of computer files is terrible.  If a file is not necessary to the functionality OF the computer, it is not functional in the way that the authors see repeated DNA sequences.

edited to put right quote up front

--------------
But I get the trick question- there isn't any such thing as one molecule of water. -JoeG

And scientists rarely test theories. -Gary Gaulin

   
Daniel Smith



Posts: 970
Joined: Sep. 2007

(Permalink) Posted: Mar. 09 2008,11:10   

Quote (JAM @ Mar. 08 2008,17:10)
     
Quote (Daniel Smith @ Mar. 08 2008,11:14)
     
Quote (JAM @ Mar. 08 2008,00:26)
         
Quote (Daniel Smith @ Mar. 07 2008,19:25)

"If you search their paper for the partial term "reproduc" (which should catch all references to reproduction) there are only three matches (and the other two are about reproductive isolation)."

The question was about the data, not about the text.

Can't you distinguish the difference?

Yes.  They present no data on reproduction rates for the organisms discussed.

So why your brain-dead text search as a response?

Isn't the point that their claim:
     
Quote
Rapidly reproducing organisms, like Caenorhabditis,
Drosophila, Fugu and Arabidopsis tend to have stripped-down
genomes with relatively less abundant repetitive DNA, while
organisms with longer life cycles, such as humans and
maize, have larger genomes with correspondingly more
repetitive elements (Table 1 ; Cavalier-Smith, 1985).


Is not only false, but utterly unsupported by the data in Table 1?


Let's look at the claim:
     
Quote
The second overlooked aspect is the significance of
genome size and of distance between distinct regions of the
genome
. Rapidly reproducing organisms, like Caenorhabditis,
Drosophila, Fugu and Arabidopsis tend to have stripped-down
genomes
with relatively less abundant repetitive DNA while
organisms with longer life cycles, such as humans and
maize, have larger genomes with correspondingly more
repetitive elements (Table 1 ; Cavalier-Smith, 1985).

So what do they mean by "relatively less" and "correspondingly more"?  Is it in relation to their own genome size or is it relative to the amount of repetitive elements in the other category (rapidly reproducing vs. longer life cycles)?  Since they say "stripped-down genomes with relatively less abundant repetitive DNA" and "larger genomes with correspondingly more repetitive elements" and immediately before that say that they are talking about "the significance of genome size and of distance between distinct regions of the genome", I'd say it is the latter.

From that perspective, I think the data in Table 1 does support their claim - especially if you look at the specific species mentioned.

--------------
"If we all worked on the assumption that what is accepted as true is really true, there would be little hope of advance."  Orville Wright

"The presence or absence of a creative super-intelligence is unequivocally a scientific question."  Richard Dawkins

  
oldmanintheskydidntdoit



Posts: 4999
Joined: July 2006

(Permalink) Posted: Mar. 09 2008,11:29   

Daniel, just wondering if you had any thoughts on how the humble onion fits into all of this?
 
Quote

Junk DNA, Junk Science, and The Onion Test
The onion test is a simple reality check for anyone who thinks they have come up with a universal function for non-coding DNA. Whatever your proposed function, ask yourself this question: Can I explain why an onion needs about five times more non-coding DNA for this function than a human?

How dos that fit into your understanding of the significance of genome size?

--------------
I also mentioned that He'd have to give me a thorough explanation as to *why* I must "eat human babies".
FTK

if there are even critical flaws in Gauger’s work, the evo mat narrative cannot stand
Gordon Mullings

  
JAM



Posts: 517
Joined: July 2007

(Permalink) Posted: Mar. 09 2008,13:37   

Quote (Daniel Smith @ Mar. 09 2008,11:10)
Let's look at the claim:
         
Quote
The second overlooked aspect is the significance of
genome size and of distance between distinct regions of the
genome
. Rapidly reproducing organisms, like Caenorhabditis,
Drosophila, Fugu and Arabidopsis tend to have stripped-down
genomes
with relatively less abundant repetitive DNA while
organisms with longer life cycles, such as humans and
maize, have larger genomes with correspondingly more
repetitive elements (Table 1 ; Cavalier-Smith, 1985).

So what do they mean by "relatively less" and "correspondingly more"?

They mean that they can't support their claim.
 
Quote
Is it in relation to their own genome size or is it relative to the amount of repetitive elements in the other category (rapidly reproducing vs. longer life cycles)?

Dan, the paper is pure hackery.

1) Genome size is very highly correlated with the amount of repeated DNA; in fact, because the same fundamental set of genes is there (remember how spectacularly wrong your prediction was?) and most DNA without a known function is repetitive, genome size is basically a function of the amount of repeated DNA.

2) The opposite of "rapidly reproducing" is "slowly reproducing," not "longer life cycles."
 
Quote
Since they say "stripped-down genomes with relatively less abundant repetitive DNA" and "larger genomes with correspondingly more repetitive elements" and immediately before that say that they are talking about "the significance of genome size and of distance between distinct regions of the genome", I'd say it is the latter.

It doesn't matter; it's BS either way.
 
Quote
From that perspective, I think the data in Table 1 does support their claim - especially if you look at the specific species mentioned.

Why would you italicize your bad grammar? Data (plural) either do or don't support a claim.

1) The data in the table couldn't possibly support their claim even if their claim was correct, because they offered no data on either speed of reproduction or length of life cycle (which aren't the same thing).

2) Look at two of the specific species mentioned: dog and mouse. The claimed relationship doesn't hold at all for them. IOW, they are incompetent even at dishonest cherry-picking.

If you really wanted to see if this is true, you'd look at more closely-related organisms, such as within the genus Allium. The evidence (remember, that stuff you lied about being interested in?) shows that genome size is amazingly plastic.

  
mitschlag



Posts: 236
Joined: Sep. 2006

(Permalink) Posted: Mar. 09 2008,13:55   

And now, a brief interlude, as we return to those thundering hoofs of yesteryear...
         
Quote (Tracy P. Hamilton @ Mar. 06 2008,21:20)
           
Quote (Daniel Smith @ Mar. 06 2008,19:21)
             
Quote (mitschlag @ Mar. 05 2008,04:38)
               
Quote (Daniel Smith @ Mar. 04 2008,18:33)
Schindewolf speaks at length about Orthogenesis.  If I understand it correctly, his views were that evolution followed repeatable patterns, was irreversible, eventually led to overspecialization and ultimately ended in extinction.

Of the description you quote I'd say this much applies to Schindewolf's view:                          
Quote
Orthogenesis ... refers to the idea that an evolutionary lineage changes [in a] steady, uniform way with no reversals. Species [are not] evolving steadily towards a goal, [rather the path they were set on was "decided" by the saltational event that first formed that type].  [T]his trend was [not] caused by some “mysterious inner force” (to use Simpson’s words) of the species that compelled it to evolve. [Rather, Schindewolf] would say that once a trend got started in a lineage, it would unchangingly continue until extinction occurred.

Thanks for the clarification.

GG Simpson and others who worked in the field found that Schindewolf's orthogenesis theory did not fit the evidence of horse evolution:


Schindewolf used the example of horse evolution as evidence for an orthogenetic trend towards phyletic size increase. (See figures 3.130-35 on page 292)

I think your chart fairly supports that conclusion as well.

The thing I'm finding most often is that those who criticized Schindewolf often don't seem to have taken the time to try to fully understand his positions and the reasoning behind them.

florida natural history museum says

"Were all fossil horses larger than their ancestors?
Archaeohippus means ancient horse
Though many horses became larger than their ancestors, Archaeohippus actually became quite a bit smaller! Archaeohippus descended from the larger Miohippus. Nannippus is another example of a horse that was smaller than its ancestors."

Another theory slain by TWO ugly facts.


Cogent points, Tracy P. Hamilton (typically ignored by Mr Smith).  We will see more on that below, but first let's hear what Otto Heinrich Schindewolf himself had to say:
           
Quote
Schindewolf, pp. 290-291

Phyletic Increase in Size

A special case of an orthogenetic trend is size increase during the course of evolution. This may even be the essential, central process of orthogenesis and one that contributes to and effects at least a portion of the other phenomena.
<snip>
The genus Eohippus, of the Lower Eocene of North America, which stands at the beginning of the horse lineage, had a shoulder height of twenty-five centi­meters and was the size of a cat. The subsequent forms were, in order, the size of a fox terrier and then of a sheep before gradually attaining the size and proportions of the modern horse. A yardstick for the increase in size is provided by the series of skulls of some horse forms, shown to scale in figure 3.109, and by the reconstructions in figures 3.130—35. A further example is the evolution of camels, which also begins with dwarf species about the size of a rabbit, miniatures of the Recent representatives (pl.27A).

In these examples, the size of the body increases with the approach to modern times, and the Recent forms, as the provisional terminal stages of the lineages in question, are the largest of their respective kinds...

Here is GG Simpson's rejoinder:
     
Quote
GG Simpson, The Meaning of Evolution, revised 1967, pp. 136-137:

The horses even provide us with exceptions to the rule that animals tend to increase in size in their evolution. Dur­ing the Eocene the record, contrary to a rather general im­pression, does not show any net or average increase in size. In fact the known late Eocene horses average rather smaller than eohippus in the early Eocene. Then still later, in the Miocene and Pliocene, there were at least three different branches of the horse family characterized by miniature or decreased size (Archaeohippus, Nannippus, Calippus), while at the same time other lines were, according to “rule,” in­creasing in size. At that time, too, others were fluctuating around a mean size without notable change and still others developed different species of decidedly different sizes — as, indeed, is the case in Equus today.

There is increasing evidence that mammals in general, especially some of the relatively large forms, have tended to decrease in average size since the Pleistocene ice age. In it­self this negates any invariability in the rule of increase of size, and it certainly strongly suggests adaptive response to climatic conditions as opposed to size control by some inner tendency or life urge within the organisms alone. We know that climates have tended to become warmer since the Pleistocene. We also know that closely related living mam­mals show the adaptive phenomenon of being, on an average, relatively smaller in warmer climates. It is certainly reason­able to suppose that this is the same sort of phenomenon in­volved in size decrease from Pleistocene to Recent.

To be concluded...

--------------
"You can establish any “rule” you like if you start with the rule and then interpret the evidence accordingly." - George Gaylord Simpson (1902-1984)

  
mitschlag



Posts: 236
Joined: Sep. 2006

(Permalink) Posted: Mar. 09 2008,13:56   

Otto Heinrich, the cherry-picker:
 
Quote
Schindewolf, pp. 291-295 (continuing from the previous excerpt):

...And yet, this [he means inexorable increase in size] is by no means always the case; extremely often it is just the opposite, that extinct, ancient animal forms are characterized by unusual size, and the layman is indeed inclined to imagine these, without exception, as gigantic monsters.

In fact, we know that among extinct tigers, bears, elephants, rhinoceroses, and so on, there are some  extinct species that were considerably larger than those living today. A particularly conspicuous example is the mighty Baluchitherium, from the Oligocene of Asia, which is assigned to the rhinoceros group even though (like most ancient rhinoceroses) it has no horn on its nose (fig. 3.136). The shoulder height of this animal comes to about 5.3 meters, and the length of the torso is as much as 10 meters, making it one of the largest terrestrial mammals that ever lived. The enormous size of this animal is clearly seen in the comparison of a reconstruction of Baluchitherium with the Recent Indian rhi­noceros, both shown to scale in figure 3. 137.

These examples, however, by no means represent a contradiction to our rule of phyletic increase in size, for the extinct forms in question are not the imme­diate predecessors of the smaller Recent species. They are only members of a broader, related group within which they represent the terminal forms of extinct collateral lines (fig. 3.138). To this extent, they thoroughly confirm the general rule that gigantic forms mark the end of evolution.

Unquestionable examples of a once-attained body size being secondarily re­duced are almost unknown except in instances where such a reduction is suc­ceeded by a thorough remodeling to a completely new typal structure, which, itself, begins again with small forms. The exceptions occasionally cited are prob­ably only apparent, for in those cases it has not been shown that the forms with the supposed reduction in size really issued from larger ancestral forms of the same genetic lineage; only in such a situation would our rule be contradicted.

Accordingly, the evolution of size is, in general, irreversible. However, it is immediately clear that gigantic forms are indicators of dying lineages, for ulti­mately a point would be reached beyond which continued increase in size would be impossible for physiological reasons.

However, you are full of it, Schindewolf:
 
Quote
Simpson, op. cit., pp.137-138:

In this connection, it is known that many large animals of the past became extinct and are not the ancestors of their smaller living relatives. Mammoths were not ancestral to smaller elephants. (As a matter of fact, most mammoths were no larger than some living elephants, but a few were.) The elephantine ground sloths were not ancestral to the little living tree sloths. The dinosaurs were not the ancestors of the small lizards of later times. But this does not mean that forms that were the ancestors of living animals were not also somewhat larger than the latter at one time or another, and such does appear to be the case for some of them.

Some paleontologists have been so impressed by the fre­quent trend for animals to become larger as time goes on that they have tried to work it the other way around. If they find, say, a Pleistocene bison that is somewhat larger than a Recent bison (so-called Bison taylori, associate and prey of early man in America, is a good example), then they conclude that it is not ancestral to later bison because it is larger. You can establish any “rule” you like if you start with the rule and then interpret the evidence accordingly.

That last line is a keeper.

--------------
"You can establish any “rule” you like if you start with the rule and then interpret the evidence accordingly." - George Gaylord Simpson (1902-1984)

  
JAM



Posts: 517
Joined: July 2007

(Permalink) Posted: Mar. 09 2008,16:20   

Quote (Daniel Smith @ Mar. 08 2008,15:26)
Let me just clarify something here.

You misspelled "obfuscate."
   
Quote
Schindewolf did not spend a lot of time talking about genetic mechanisms because he was not a genetecist.

So what? Dan, we're talking about a false claim that he made about genetics. Not being a geneticist is no excuse for making a false claim. Schindewolf had zero excuse for not knowing the relevant genetics.
   
Quote
He knew however, that there had to be some form of mechanism because he saw evidence for it in the fossil record.

But he was WRONG about the mechanism, just as he was wrong about the horse data. It's that simple.
   
Quote
He produced extensive data (JAM) documenting the reality of an ontogenetic switch from an established developmental path to a new and different developmental pathway during the early ontogenetic stages of fossilized ammonites and corals.

He produced exactly ZERO data to support his claim about the genetic mechanisms underlying the "switches." If he really was interested in testing his hypothesis, he would have observed and documented the huge morphological gaps WITHIN coral species AND EVEN WITHIN INDIVIDUAL COLONIES. I pointed you to that evidence, and you, proving beyond any doubt that you were lying when you claimed to want to see the evidence for yourself, ignored it.

Schindewolf was wrong. Deal with it.
   
Quote
So he knew evolution happened that way - he had observed it as directly as a paleontologist could - he just didn't know what exact mechanism was behind the observed switch.

And he hypothesized a mechanism, but could not be bothered to test his hypothesis. He was wrong.
   
Quote
He embraced Goldschmidt's systemmutationen because it closely resembled his own observations,...

Now you're just lying. It didn't "resemble his observations." Even if it *was consistent with* them, it still wasn't consistent with the data that we have now, and that you so dishonestly ignore.

Why did you lie and claim to be interested in evidence, Dan?
   
Quote
... but the switch does not have to be chromosomal rearrangements,...

Uh, Dan, the huge differences we observe within living coral species and colonies suggest that most of that morphological variation isn't even genetic.
[/quote] it could be single nucleotide substitutions (I suppose) provided they affected an early enough stage in ontogeny.[/quote]
Even then, it doesn't contradict neo-Darwinian evolutionary theory at all. Single-nucleotide substitutions are the smallest particulate change possible.
 
Quote
The point being, Schindewolf's theory was based on his direct observations of 'ontogenetical evolution' in the fossil record (as "direct" as can be deduced from the fossil record that is).

The point being that his hypothesis made clear predictions about what he would not be observed within live coral species. He didn't test his hypothesis. Other people did, and it's not consistent with the data. That's why his hypothesis is on the trash heap of science. His data are still useful.

  
mitschlag



Posts: 236
Joined: Sep. 2006

(Permalink) Posted: Mar. 09 2008,17:27   

Quote (JAM @ Mar. 09 2008,16:20)
That's why his hypothesis is on the trash heap of science. His data are still useful.

Gotta give credit where credit is due.

And it's due.

--------------
"You can establish any “rule” you like if you start with the rule and then interpret the evidence accordingly." - George Gaylord Simpson (1902-1984)

  
Daniel Smith



Posts: 970
Joined: Sep. 2007

(Permalink) Posted: Mar. 09 2008,19:17   

Quote (JAM @ Mar. 09 2008,11:37)
 
Quote (Daniel Smith @ Mar. 09 2008,11:10)
Let's look at the claim:
             
Quote
The second overlooked aspect is the significance of genome size and of distance between distinct regions of the genome. Rapidly reproducing organisms, like Caenorhabditis, Drosophila, Fugu and Arabidopsis tend to have stripped-down genomes with relatively less abundant repetitive DNA while
organisms with longer life cycles, such as humans and
maize, have larger genomes with correspondingly more
repetitive elements (Table 1 ; Cavalier-Smith, 1985).

So what do they mean by "relatively less" and "correspondingly more"?

They mean that they can't support their claim.
     
Quote
Is it in relation to their own genome size or is it relative to the amount of repetitive elements in the other category (rapidly reproducing vs. longer life cycles)?

Dan, the paper is pure hackery.

1) Genome size is very highly correlated with the amount of repeated DNA; in fact, because the same fundamental set of genes is there (remember how spectacularly wrong your prediction was?) and most DNA without a known function is repetitive, genome size is basically a function of the amount of repeated DNA.

2) The opposite of "rapidly reproducing" is "slowly reproducing," not "longer life cycles."
     
Quote
Since they say "stripped-down genomes with relatively less abundant repetitive DNA" and "larger genomes with correspondingly more repetitive elements" and immediately before that say that they are talking about "the significance of genome size and of distance between distinct regions of the genome", I'd say it is the latter.

It doesn't matter; it's BS either way.
     
Quote
From that perspective, I think the data in Table 1 does support their claim - especially if you look at the specific species mentioned.

Why would you italicize your bad grammar? Data (plural) either do or don't support a claim.

1) The data in the table couldn't possibly support their claim even if their claim was correct, because they offered no data on either speed of reproduction or length of life cycle (which aren't the same thing).

2) Look at two of the specific species mentioned: dog and mouse. The claimed relationship doesn't hold at all for them. IOW, they are incompetent even at dishonest cherry-picking.

If you really wanted to see if this is true, you'd look at more closely-related organisms, such as within the genus Allium. The evidence (remember, that stuff you lied about being interested in?) shows that genome size is amazingly plastic.

I'm looking at the Allium paper right now and I can see what you're talking about w/regard to genome size.  Looking at the data, I notice that all the species from the Subgenus Amerallium have larger genomes.  The authors also note "a correlation between genome size and ploidy level", but it doesn't seem to me to be a strong correlation.
Quote
A comparative analysis conducted using Mesquite (Maddison and Maddison 2003) revealed the existence of a correlation between genome size and ploidy level (Fig. 2, P = 0.031): tetraploidy is correlated with a small genome size.

Nevertheless, I think I'm in way over my head on this one!  I will defer to you that the paper proves your point.  I'm not going to be able to defend the Shapiro/Sternberg paper very effectively - I'm just too new to this.  I've made the mistake in the past of making grandiose claims that I could not back up and I'm beginning to see the error of my ways.  So, the Shapiro/Sternberg paper must stand or fall on its own merits.

--------------
"If we all worked on the assumption that what is accepted as true is really true, there would be little hope of advance."  Orville Wright

"The presence or absence of a creative super-intelligence is unequivocally a scientific question."  Richard Dawkins

  
Daniel Smith



Posts: 970
Joined: Sep. 2007

(Permalink) Posted: Mar. 09 2008,19:55   

Quote (JAM @ Mar. 09 2008,14:20)
   
Quote (Daniel Smith @ Mar. 08 2008,15:26)
Let me just clarify something here.

You misspelled "obfuscate."
         
Quote
Schindewolf did not spend a lot of time talking about genetic mechanisms because he was not a genetecist.

So what? Dan, we're talking about a false claim that he made about genetics. Not being a geneticist is no excuse for making a false claim. Schindewolf had zero excuse for not knowing the relevant genetics.
         
Quote
He knew however, that there had to be some form of mechanism because he saw evidence for it in the fossil record.

But he was WRONG about the mechanism, just as he was wrong about the horse data. It's that simple.
         
Quote
He produced extensive data (JAM) documenting the reality of an ontogenetic switch from an established developmental path to a new and different developmental pathway during the early ontogenetic stages of fossilized ammonites and corals.

He produced exactly ZERO data to support his claim about the genetic mechanisms underlying the "switches." If he really was interested in testing his hypothesis, he would have observed and documented the huge morphological gaps WITHIN coral species AND EVEN WITHIN INDIVIDUAL COLONIES. I pointed you to that evidence, and you, proving beyond any doubt that you were lying when you claimed to want to see the evidence for yourself, ignored it.

Schindewolf was wrong. Deal with it.
         
Quote
So he knew evolution happened that way - he had observed it as directly as a paleontologist could - he just didn't know what exact mechanism was behind the observed switch.

And he hypothesized a mechanism, but could not be bothered to test his hypothesis. He was wrong.
         
Quote
He embraced Goldschmidt's systemmutationen because it closely resembled his own observations,...

Now you're just lying. It didn't "resemble his observations." Even if it *was consistent with* them, it still wasn't consistent with the data that we have now, and that you so dishonestly ignore.

Why did you lie and claim to be interested in evidence, Dan?
         
Quote
... but the switch does not have to be chromosomal rearrangements,...

Uh, Dan, the huge differences we observe within living coral species and colonies suggest that most of that morphological variation isn't even genetic.
 
Quote
it could be single nucleotide substitutions (I suppose) provided they affected an early enough stage in ontogeny.

Even then, it doesn't contradict neo-Darwinian evolutionary theory at all. Single-nucleotide substitutions are the smallest particulate change possible.
       
Quote
The point being, Schindewolf's theory was based on his direct observations of 'ontogenetical evolution' in the fossil record (as "direct" as can be deduced from the fossil record that is).

The point being that his hypothesis made clear predictions about what he would not be observed within live coral species. He didn't test his hypothesis. Other people did, and it's not consistent with the data. That's why his hypothesis is on the trash heap of science. His data are still useful.

To be fair to Schindewolf, at the time of the books printing, he was "not yet familiar" with Goldschmidt's The Material Basis of Evolution though he says that Goldschmidt's "earlier communications on this subject" had "considerable influence" on his thinking.  He says quite specifically that    
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the concepts described here grew out of my own analysis of the paleontological material.
 
The genetic mechanism of chromosome repatterning was not even mentioned in the first printing of his book.  He only mentioned it in subsequent footnotes.
In the original publication he makes the case for an ontogenetic change of developmental direction.  In fact, on page 353, Fig. 3.156, he charts his views of the ontogentic switch:    
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Consequently, there is no fundamental difference between micromutations... and macromutations, which appear in early stages and are distinguished only by the profoundness of their effects.

So his embracing of Goldschmidt's mechanism was based on, as he put it, "the broad agreement in our views" with the caveat that "Goldschmidt goes further than I and is in a position to support his phylogenetic conclusions genetically."

So, I've made a mish-mash out of Schindewolf's case by conflating it with Goldschmidt's.  

As for the evidence presented regarding the horse and living corals, I'll have to give all of it some thought.  Was the coral evidence the picture you posted?

--------------
"If we all worked on the assumption that what is accepted as true is really true, there would be little hope of advance."  Orville Wright

"The presence or absence of a creative super-intelligence is unequivocally a scientific question."  Richard Dawkins

  
JAM



Posts: 517
Joined: July 2007

(Permalink) Posted: Mar. 09 2008,23:26   

Quote (Daniel Smith @ Mar. 09 2008,19:17)
I'm looking at the Allium paper right now and I can see what you're talking about w/regard to genome size.  Looking at the data, I notice that all the species from the Subgenus Amerallium have larger genomes.  The authors also note "a correlation between genome size and ploidy level", but it doesn't seem to me to be a strong correlation.    
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A comparative analysis conducted using Mesquite (Maddison and Maddison 2003) revealed the existence of a correlation between genome size and ploidy level (Fig. 2, P = 0.031): tetraploidy is correlated with a small genome size.

Nevertheless, I think I'm in way over my head on this one!

I salute you for being honest. At the risk of pissing you off, I hope that I can get you to understand that you are in over your head because you are placing opinion above evidence. When you arrived here, there seemed to be hope because you claimed to be interested in evidence and you seemed to be interested until your predictions were all shown to be wrong. Then you reverted to standard IDer/creationist behavior.
 
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I will defer to you that the paper proves your point.

You should never grant that ANYTHING is proven in science. We don't deal in proof--that's the best way to put evidence above opinion, even expert opinion.
 
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I'm not going to be able to defend the Shapiro/Sternberg paper very effectively - I'm just too new to this.

You don't have to understand the minutiae of the field to see that it is hackery--all you need to do is to see whether Shapiro or Sternberg have produced any data in the process of testing the hypothesis you find so appealing. They haven't and they won't.
 
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I've made the mistake in the past of making grandiose claims that I could not back up and I'm beginning to see the error of my ways.

Good! Can you see the error of Sternberg's? Of Behe's? Of Schindewolf's?
 
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So, the Shapiro/Sternberg paper must stand or fall on its own merits.

It doesn't have any. Here's why you're getting in trouble:

Your method: start with a hypothesis you find appealing and look for quotes that agree or seem to agree with your POV.

The scientific method: start with the evidence, try to explain the evidence with a hypothesis, and then do everything you can to demolish YOUR OWN hypothesis (or anyone else's hypothesis with which you become enamored) before you come to any conclusion, which still is only provisional--nothing is ever proven.

Your method is instinctive and easy. The scientific method goes against our instincts, but is the most powerful way to gain practical understanding about nature.

Are you beginning to see that even famous, productive scientists can lose track of the scientific method when they yield to ego and instinct, but that lay people, armed only with an understanding of the scientific method, can easily determine when this happens?

If Schindewolf had been a truly great scientist, he would have studied living corals. Being unable to move into a new field is an incredibly lame excuse.

  
Daniel Smith



Posts: 970
Joined: Sep. 2007

(Permalink) Posted: Mar. 10 2008,10:58   

Quote (JAM @ Mar. 09 2008,21:26)
 
Quote (Daniel Smith @ Mar. 09 2008,19:17)
I'm looking at the Allium paper right now and I can see what you're talking about w/regard to genome size.  Looking at the data, I notice that all the species from the Subgenus Amerallium have larger genomes.  The authors also note "a correlation between genome size and ploidy level", but it doesn't seem to me to be a strong correlation.      
Quote
A comparative analysis conducted using Mesquite (Maddison and Maddison 2003) revealed the existence of a correlation between genome size and ploidy level (Fig. 2, P = 0.031): tetraploidy is correlated with a small genome size.

Nevertheless, I think I'm in way over my head on this one!

I salute you for being honest. At the risk of pissing you off, I hope that I can get you to understand that you are in over your head because you are placing opinion above evidence. When you arrived here, there seemed to be hope because you claimed to be interested in evidence and you seemed to be interested until your predictions were all shown to be wrong. Then you reverted to standard IDer/creationist behavior.
   
Quote
I will defer to you that the paper proves your point.

You should never grant that ANYTHING is proven in science. We don't deal in proof--that's the best way to put evidence above opinion, even expert opinion.
   
Quote
I'm not going to be able to defend the Shapiro/Sternberg paper very effectively - I'm just too new to this.

You don't have to understand the minutiae of the field to see that it is hackery--all you need to do is to see whether Shapiro or Sternberg have produced any data in the process of testing the hypothesis you find so appealing. They haven't and they won't.
   
Quote
I've made the mistake in the past of making grandiose claims that I could not back up and I'm beginning to see the error of my ways.

Good! Can you see the error of Sternberg's? Of Behe's? Of Schindewolf's?
   
Quote
So, the Shapiro/Sternberg paper must stand or fall on its own merits.

It doesn't have any. Here's why you're getting in trouble:

Your method: start with a hypothesis you find appealing and look for quotes that agree or seem to agree with your POV.

The scientific method: start with the evidence, try to explain the evidence with a hypothesis, and then do everything you can to demolish YOUR OWN hypothesis (or anyone else's hypothesis with which you become enamored) before you come to any conclusion, which still is only provisional--nothing is ever proven.

Your method is instinctive and easy. The scientific method goes against our instincts, but is the most powerful way to gain practical understanding about nature.

Are you beginning to see that even famous, productive scientists can lose track of the scientific method when they yield to ego and instinct, but that lay people, armed only with an understanding of the scientific method, can easily determine when this happens?

If Schindewolf had been a truly great scientist, he would have studied living corals. Being unable to move into a new field is an incredibly lame excuse.

JAM,

Can you please point me again to the living coral evidence you spoke about?

Thanks.

--------------
"If we all worked on the assumption that what is accepted as true is really true, there would be little hope of advance."  Orville Wright

"The presence or absence of a creative super-intelligence is unequivocally a scientific question."  Richard Dawkins

  
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