Joined: Feb. 2006
The liars at UD are at it again.
Mario Lopez quotes a recent article from Nature as
Molecular biology: The Bloom's complex mousetrap
Robert M. Brosh, Jr
Nature 456, 453-454 (27 November 2008)
2. “The BLM protein complex consists of several components, much like a mousetrap. With all the parts properly assembled, the mousetrap will operate efficiently and catch the mouse. In this case, a DNA structure called a double Holliday junction is caught in the BLM complex. Xu et al. and Singh et al. report the discovery of a component of this complex, RMI2, which stabilizes and orchestrates the action of the BLM complex, ensuring resolution of the double Holliday junction, and so promoting chromosomal stability.”
3. “As for the significance of RMI2 to the BLM complex, for analogy let’s imagine a mousetrap. It contains several components, including a spring, a platform, a hammer, a hold-down bar and a catch. Omit certain components of the trap, and the device may still operate, albeit less efficiently. With all of the components in place – including those with primarily structural roles such as the hold-down bar and the platform – the trap is most likely to catch the mouse. Returning to the BLM complex: through its interaction with RMI1, RMI2 allows the ‘BLM–Topo-3alpha device’ to assume optimal stability and configuration so that it can efficiently catalyse the splitting of the double Holliday junction, and so prevent the escape of deleterious DNA structures that would lead to crossovers (Fig. 1). RMI2 therefore seems to have an integral structural role in the BLM–Topo-3alpha device by orchestrating its action.”
4. “Darwinian scenarios, either for building mousetraps or biochemical systems, are very easy to believe if we aren’t willing or able to scrutinize the smallest details, or to ask for experimental evidence. They invite us to admire the intelligence of natural selection. But the intelligence we are admiring is our own.”
The big problem is - only paragraphs 2 and 3 are from the paper. Paragraph 4 is an addition by Lopez taken from a 2000 Behe article at the Disco 'tute, set up to look like Lopez is quoting the same paper. The actual concluding paragraphs are:
|What are the implications of these observations? Mutations in the gene encoding RMI2 are likely to occur in hereditary diseases characterized by chromosomal instability and cancer. It is provocative, therefore, that there is a connection between the BLM complex and proteins mutated in another genetic disorder called Fanconi's anaemia, which also carries a high risk of cancer.|
The core protein complex affected in Fanconi's anaemia (FA) and the BLM complex associate together in a supercomplex known as BRAFT (BLM, RPA, FA and Topo 3alpha)6. Singh and colleagues4 identify FA proteins in complexes containing RMI2 and BLM, consistent with previous findings that BLM and its associated factors collaborate with FA proteins in response to replicational stress7, 8. So an emerging theme from these studies is that a complex network of proteins that work through overlapping and interacting pathways confers genomic integrity. To understand the functional mechanism of these protein complexes, every 'mousetrap device' must be dissected one by one. Understanding how the trap catches the mouse will allow us to grasp the consequences of chromosomal instability associated with cancer and other diseases.
These IDiots can't go a single day without posting some sort of lies and deception. Baby Jesus is gonna bawl his eyes out tonight.
"Science is what got us to the humble place weâ€™re at, and what hard-won progress we might realize comes from science, with ID completely flaccid, religious apologetics bitching from the sidelines." - Eigenstate at UD