Wesley R. Elsberry
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Posts: 4991 Joined: May 2002
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Quote (Daniel Smith @ Oct. 25 2008,15:46) | Quote (Wesley R. Elsberry @ Oct. 24 2008,14:12) | Quote (Daniel Smith @ Oct. 24 2008,12:26) | Here's Michael Behe's take on the paper Wesley cited on the Krebs' cycle (It's in the section responding to Kenneth Miller): Quote | Finally Miller discusses a paper which works out a scheme for how the organic-chemical components of the tricarboxylic acid (TCA) cycle, a central metabolic pathway, may have arisen gradually. (Melendez-Hevia et al. 1996) There are several points to make about it. First, the paper deals with the chemical interconversion of organic molecules, not the enzymes of the pathway or their regulation. As an analogy, suppose someone described how petroleum is refined step by step, beginning with crude oil, passing through intermediate grades, and ending with, say, gasoline. He shows that the chemistry of the processes is smooth and continuous, yet says nothing about the actual machinery of the refinery or its regulation, nothing about valves or switches. Clearly that is inadequate to show refining of petroleum developed step by step. Analogously, someone who is seriously interested in showing that a metabolic pathway could evolve by Darwinian means has to deal with the enzymic machinery and its regulation. |
Now Behe is a biochemist, so I think he's qualified to critique a highly technical paper. |
Wow... another paper that Behe didn't actually read. From the caption in Figure 2:
Quote | Enzymes: (1) synthase, (2, 3) isomerase, (4) dehydrogenase, (5) aldehyde dehydrogenase, (6) kinase, (7) succinate dehydrogenase, (8) fumarase, (9) malate dehydrogenase, (10) oxaloacetate decarboxylase.
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There seem to be a number of enzymes in the discussion for a paper that, according to Behe, doesn't mention any. |
I think what Behe was objecting to was not whether they mentioned enzymes or not, but whether they explained their origin (if new ones are required) and their regulation. Any metabolic pathway contains enzymes, to think that he was implying that theirs didn't is, I think, a strawman. |
Really?
Quote | [...] yet says nothing about the actual machinery of the refinery or its regulation, nothing about valves or switches [...]
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Love those standards of yours, twice the size of other people's.
-------------- "You can't teach an old dogma new tricks." - Dorothy Parker
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