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  Topic: immune system evolution, collecting references to recent articles< Next Oldest | Next Newest >  
rafe gutman

Posts: 27
Joined: May 2002

(Permalink) Posted: April 05 2003,16:47   

this is more of a reminder to myself to read this article, since it is now freely available online:


Roth DB.
From lymphocytes to sharks: V(D)J recombinase moves to the germline.
Genome Biol. 2000;1(2):REVIEWS1014. Review.

The antigen-receptor genes of vertebrates are rearranged by a specialized somatic recombination mechanism in developing lymphocytes - and, unexpectedly, also in the germline of cartilaginous fishes. The recombination system that carries out these DNA rearrangements may thus be a significant evolutionary force, perhaps not limited to rearrangements at antigen-receptor loci.

  23 replies since Dec. 17 2002,18:45 < Next Oldest | Next Newest >  


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