Joined: May 2002
this is more of a reminder to myself to read this article, since it is now freely available online:
From lymphocytes to sharks: V(D)J recombinase moves to the germline.
Genome Biol. 2000;1(2):REVIEWS1014. Review.
The antigen-receptor genes of vertebrates are rearranged by a specialized somatic recombination mechanism in developing lymphocytes - and, unexpectedly, also in the germline of cartilaginous fishes. The recombination system that carries out these DNA rearrangements may thus be a significant evolutionary force, perhaps not limited to rearrangements at antigen-receptor loci.