rafe gutman
Posts: 27 Joined: May 2002
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this is more of a reminder to myself to read this article, since it is now freely available online:
http://genomebiology.com/2000/1/2/REVIEWS/1014
| Quote | Roth DB. From lymphocytes to sharks: V(D)J recombinase moves to the germline. Genome Biol. 2000;1(2):REVIEWS1014. Review.
abstract: The antigen-receptor genes of vertebrates are rearranged by a specialized somatic recombination mechanism in developing lymphocytes - and, unexpectedly, also in the germline of cartilaginous fishes. The recombination system that carries out these DNA rearrangements may thus be a significant evolutionary force, perhaps not limited to rearrangements at antigen-receptor loci. |
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