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  Topic: Protein folding and evolution, How protein folds evolve< Next Oldest | Next Newest >  

Posts: 97
Joined: May 2002

(Permalink) Posted: Mar. 23 2004,10:59   

Nat Struct Mol Biol. 2004 Mar 14

A novel ADP- and zinc-binding fold from function-directed in vitro evolution.

Surdo PL, Walsh MA, Sollazzo M.

A great challenge to biologists is to create proteins with novel folds and tailored functions. As an alternative to de novo protein design, we investigated the structure of a randomly generated protein targeted to bind ATP. The crystal structure reveals a novel alpha/beta fold bound to its ligand, representing both the first protein structure derived from in vitro evolution and the first nucleotide-binding protein stabilized by a zinc ion.


  3 replies since Dec. 20 2002,01:15 < Next Oldest | Next Newest >  


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