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  Topic: Uncommon Dissent: Intellectuals Who Find Darwinism, Comments, links, etc.< Next Oldest | Next Newest >  

Posts: 319
Joined: May 2002

(Permalink) Posted: July 24 2003,14:38   

PLA writes,


Question for Nic:

Do you think Melendez-Hevia et al. 1996 have explained the origin of the Krebs citric acid cycle? In other words, should the rest of the scientific community now consider that problem solved?
I would say that they achieved a reasonably detailed approximation of the True Full Explanation.  Like everything in science, improvements are always possible.  Also, not absolutely everything one might want to know should be expected to be in that single paper, it is built on a large number of papers cited, e.g.:


References [cutting those not specifically on the topic]

Baldwin JE, Krebs H (1981) The evolution of metabolic cycles. Nature 291:381–382

Buchanan BB, Arnon DI (1990) A reverse Krebs cycle in photosynthesis: consensus at last. Photosynth Res 24:47–53

Evans MCW, Buchanan BB, Arnon DI (1966) A new ferredoxindependent carbon reduction cycle in a photosynthetic bacterium. Proc Natl Acad Sci USA 55:928–934

Gest H (1981) Evolution of the citric acid cycle and respiratory energy conversion in prokaryotes. FEMS Microbiol Lett 12:209–215

Gest H (1987) Evolutionary roots of the citric acid cycle in prokaryotes. Biochem Soc Symp 54:3–16

Jacob F (1977) Evolution and tinkering. Science 196:1161–1166

Mason SF (1992) Chemical evolution. Clarendon Press, Oxford, pp 122–128

Mele´ndez-Hevia E (1990) The game of the pentose phosphate cycle: a mathematical approach to study the optimization in deisgn of metabolic pathways during evolution. Biomed Biochim Acta 49:903– 916

Mele´ndez-Hevia E, Isidoro A (1985) The game of the pentose phosphate cycle. J Theor Biol 117:251–263

Mele´ndez-Hevia E, Torres NV (1988) Economy of design in metabolic pathways: further remarks on the pentose phosphate cycle. J Theor Biol 132:97–111

Mele´ndez-Hevia E, Waddell TG, Shelton ED (1993) Optimization of molecular design in the evolution of metabolism: the glycogen molecule. Biochem J 295:477–483

Mele´ndez-Hevia E, Waddell TG, Montero F (1994) Optimization of metabolism: the evolution of metabolic pathways toward simplicity through the game of the pentose phosphate cycle. J Theor Biol 166:201–220

Mortlock RP (ed) (1992) Evolution of metabolic function. CRC Press, Boca Raton, FL

Schauder R, Eikmanns B, Thauer RK, Widdel F, Fuchs G (1986) Acetate oxidation to CO2 in anaerobic bacteria via a novel pathway not involving reactions of the citric acid cycle. Arch Microbiol 145:162–172

Thauer RK (1988) Citric acid cycle, 50 years on. Modifications and an alternative pathway in bacteria. Eur J Biochem 176:497–508

Waddell TG, Geevarghese SK, Henderson BS, Pagni RM, Newton JS (1989) Chemical evolution of the citric acid cycle: sunlight and ultraviolet photolysis of cycle intermediates. Orig Life 19:603–607

Waddell TG, Henderson BS, Morris RT, Lewis CM, Zimmermann AG (1987) Chemical evolution of the citric acid cycle: sunlight photolysis of a-ketoglutaric acid. Orig Life 17:149–153

Waddell TG, Miller TJ (1992) Chemical evolution of the citric acid cycle: sunlight photolysis of the aminoacids glutamate and aspartate. Orig Life 21:219–223

Weitzman PDJ (1985) Evolution of the citric acid cycle. In: Schleifer KH, Stackebrandt E (eds) Evolution of prokaryotes, Academic Press, London, pp 253–273
And research following this paper has advanced things even further:

Link to 175 related articles (some before, some after 1996)

A question for you, PLA: how much of this literature would you have expected to exist, if you relied on Dembski for your information?

  11 replies since July 22 2003,20:51 < Next Oldest | Next Newest >  


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