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  Topic: MHC/HLA immune genome mutation rates question< Next Oldest | Next Newest >  
Friar Broccoli



Posts: 5
Joined: Jan. 2014

(Permalink) Posted: Jan. 18 2014,16:08   

[quote=Soapy Sam,Jan. 18 2014,12:50][/quote]
 
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http://www.pnas.org/content....ull.pdf


Thanks for suggesting this article.  It is now obvious to me that I need to read up on mhc in primates and long isolated human populations like Australian Aborigines and Native Americans.  Don't know what I'll find but should see something useful.

 
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This selection was in train in ancestral pre-human lineages as well, so we descend from a long line of polymorphic species. How it transcends the apparent human population bottleneck of as few as 10,000 individuals, I'm not so sure. But you can't assume a single allele at the 'dawn of man', or any intervening point.


I am interested in assuming 8 alleles 4500 years ago (or two 6,000 years ago) and establishing that it is impossible.


 
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and you don't just multiply it down a single lineage, as noted by qetzal. Each time a lineage splits, twice as many mutations are separating their MHCs than happen in each separate line; split them a few more times and you could soon get 1000 different versions, even if each individual lineage only experienced a few mutations.


I suspected this was the problem.  I will probably need to figure out some other way of making the argument.

  
  11 replies since Jan. 17 2014,12:06 < Next Oldest | Next Newest >  

    


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