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Dr.GH



Posts: 1954
Joined: May 2002

(Permalink) Posted: Nov. 08 2011,09:08   

Quote (Southstar @ Nov. 08 2011,06:01)
http://www.sciencemag.org/content........636


Sorry this is the correct link to the study

This is the "money quote" on mutation rates from the cited article;

Quote

Although both the observed transition-to-transversion ratio and the proportion of CpG mutations in our data match predictions, our estimated human mutation rate is lower than previous estimates, the most widely cited of which is 2.5 10^-8 per generation (10) based on three parameters: a human-chimpanzee nucleotide divergence per site (Kt) of 0.013, a species divergence time of 5 million years ago, and an ancestral effective population size of 10,000. More recent estimates indicate a nucleotide divergence of 0.012 (9), species divergence time between 6 and 7 million years ago (1115), and ancestral effective population size between 40,000 and 148,000 (1619). With these parameter ranges and a generation length of 15 to 25 years, the mutation rate estimate is between 7.6 10^-9 and 2.2 10^-8 per generation, which is consistent with our intergenerational estimate of 1.1 10^-8. Our estimate is within 1 SD of an earlier estimate of 1.7 10^-8 (SD of 9 10^-9) based on 20 disease-causing loci (20). The rate we report is for autosomes and should be substantially lower than that of the Y chromosome because in the male germ line, more cell divisions occur per generation. Although our rate differs approximately as expected from the recently reported estimate of 3.0 10^-8 (95% CI, 8.9 10^-9 to 7.0 10^-8) for the Y chromosome, this difference is not significant (21).
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Edited by Dr.GH on Nov. 08 2011,07:11

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"Science is the horse that pulls the cart of philosophy."

L. Susskind, 2004 "SMOLIN VS. SUSSKIND: THE ANTHROPIC PRINCIPLE"

   
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