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OgreMkV



Posts: 3350
Joined: Oct. 2009

(Permalink) Posted: Nov. 08 2011,08:07   

Quote (Southstar @ Nov. 08 2011,08:01)
http://www.sciencemag.org/content........636


Sorry this is the correct link to the study

I don't know... the 1.1 x 10^-8 seems right in line with other studies,

Rates of Spontaneous Mutation

Quote
Homo sapiens: The human data are less reliable than the C. elegans, Drosophila and mouse data. A number of dominant-mutation rates have been inferred from the frequency of affected children of normal parents, and sometimes confirmed by equilibrium estimates for those dominants with severe effects. These values range from 10-4 to 10-6, with a rough average of 10-5 (VOGEL and MOTULSKY 1997 Down). For genes of size 103 b, this corresponds to a rate of 10-8 per b per generation. An estimate based on specific changes in the hemoglobin molecule gave 0.74 x 10-8 per b per generation (VOGEL and MOTULSKY 1997 Down), but this is clearly an underestimate because other kinds of changes are not included. A third, quite independent estimate is based on rates of evolution of pseudogenes in human ancestry, which are likely to be identical to mutation rates (KIMURA 1983A Down). This gives about 2 x 10-8 per b per generation (CROW 1993 Down, CROW 1995 Down). We shall take 10-8 as a representative value. However, because the overwhelming majority of human mutations occur in males (see below), the male rate must be about twice the average rate, or 2 x 10-8.


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Ignored by those who can't provide evidence for their claims.

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