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skeptic



Posts: 1163
Joined: May 2006

(Permalink) Posted: July 18 2008,20:30   

Here's my current most-recent favorite:

Science 9 May 2008:
Vol. 320. no. 5877, pp. 811 - 814
DOI: 10.1126/science.1156093

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Reports
Regulation of the Cellular Heat Shock Response in Caenorhabditis elegans by Thermosensory Neurons
Veena Prahlad, Tyler Cornelius, Richard I. Morimoto*

Temperature pervasively affects all cellular processes. In response to a rapid increase in temperature, all cells undergo a heat shock response, an ancient and highly conserved program of stress-inducible gene expression, to reestablish cellular homeostasis. In isolated cells, the heat shock response is initiated by the presence of misfolded proteins and therefore thought to be cell-autonomous. In contrast, we show that within the metazoan Caenorhabditis elegans, the heat shock response of somatic cells is not cell-autonomous but rather depends on the thermosensory neuron, AFD, which senses ambient temperature and regulates temperature-dependent behavior. We propose a model whereby this loss of cell autonomy serves to integrate behavioral, metabolic, and stress-related responses to establish an organismal response to environmental change.

here's the link in case anyone can access the archives:

HSPs - May 2008

  
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