Joined: Sep. 2006
|Quote (afdave @ Nov. 10 2006,08:32)|
|ONLY A FEW ALLELES IN ANY ONE PARTICLUAR GEOGRAPHIC LOCATION|
You guys should quit bashing creationists and start READING them for once.
Your statements on this post (actually, Woodmorappe's statements) are ALL OVER THE PLACE. You start out with statements about MHC complex then contunue to HLA genes in general then make statements about HLA-DRB1.
Here's a playbook of definitions from Wikipedia.
|The best-known genes in the MHC region are the subset that encodes cell-surface antigen-presenting proteins. In humans, these genes are referred to as human leukocyte antigen (HLA) genes, although people often use the abbreviation MHC to refer to HLA gene products. To clarify the usage, some of the biomedical literature uses HLA to refer specifically to the HLA protein molecules and reserves MHC for the region of the genome that encodes for this molecule; however this convention is not consistently adhered to.|
The most intensely-studied HLA genes are the nine so-called classical MHC genes: HLA-A, HLA-B, HLA-C, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQB1, HLA-DRA, and HLA-DRB1. In humans, the MHC is divided into three regions: Class I, II, and III. The A, B, and C genes belong to MHC class I, whereas the six D genes belong to class II.
When we're talking about HLA-B, we are talking about one gene. NOT THE ENTIRE MHC COMPLEX. Your having a rough enough time concentrating your efforts on one gene. Don't try and take on the entire MHC complex now.
If you want to take on the entire MHC complex, let's start with this statement from the same Wikipedia page.
|One of the most striking features of the MHC, particularly in humans, is the astounding allelic diversity found therein, and especially among the nine classical genes. In humans, the most conspicuously-diverse loci, HLA-A, HLA-B, and HLA-DRB1, have roughly 250, 500, and 300 known alleles respectively -- diversity truly exceptional in the human genome. The MHC gene is the most polymorphic in the genome. And population surveys of the other classical loci routinely find tens to a hundred alleles -- still highly diverse. And perhaps even more remarkable is that many of these alleles are quite ancient: It is often the case that an allele from a particular HLA gene is more closely related to an allele found in chimpanzees than it is to another human allele from the same gene!|
WOW!!! ANCIENT ALLELES THAT RELATE TO CHIMPS BETTER THAN HUMANS. WHO'D 'AVE THUNK?
When you say this...
|And the MHC Complex is a supergene, and the closely linked genes hitch-hike with each other, thereby facilitating the origin and multiplicaiton of genetic polymorphism (Kaufman et al. 1995, p. 67)|
are you saying that gene alleles are transferrable between genes? I would like to see the whole quote in context instead of a snippet like you stated.