Bob O'H
Posts: 2564
Joined: Oct. 2005
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| Quote (sparc @ Jan. 21 2013,23:07) | Finally, someone at UD realizes that there is something like quadruplex DNA. And DLH derives predictions from its existence: | Quote | If the quadruple helix is from mutated or erroneous copying, that could be a cause of cancer. From an ID perspective, if double helix DNA was designed and the quadruple helix DNA was not, then I hypothesize that there may be detection and repair mechanisms designed to prevent the quadruple helix DNA from being formed. The underlying cause for the quadruple helix DNA may thus be failure of the detection and repair mechanisms. John C. Sanford’s studies suggest there is an accumulation of mutations in the genome over time. See Mendel’s Accountant, and Genetic Entropy and the Mystery of the Genome.
Consequently this suggests an increase in the relative frequency quadruple helix DNA to population over time. This raises the potential to identify historic mutations causing this aberration with consequent potential to detect it. |
There is bad news for DHL, however: Quadruplex DNA is conserved and often found in promoters of eukaryotic genes. Thus, it seems that G4-DNA is under evoulionary constraints and functional in non-cancer cells. Back in 1995 such sequences were described as oligopurine tracts and a young scientist concluded from their frequencies in eukaryotic genomes that they are likely functional under normal conditions:
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Even worse, there aren't "detection and repair mechanisms" acting against quadruplex DNA. Instead nuclei have thing things called "histones".
Incidentally, DLH (he should be DHL, BTW, but one of his letters was late) seems to think that quadruplex DNA is some sort of mutation, rather than being a secondary structure of DNA (albeit one that only forms when G rich).
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It is fun to dip into the various threads to watch cluelessness at work in the hands of the confident exponent. - Soapy Sam (so say we all)
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